The NCR1 Polyclonal Antibody (CAB14499) is a valuable tool for researchers studying NCR1, a natural cytotoxicity receptor involved in the innate immune response to viral infections and tumor surveillance. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By targeting the NCR1 protein, this antibody allows for the detection and analysis of NCR1 expression in various cell types, making it ideal for investigations in immunology, virology, and oncology research.
NCR1, also known as NKp46, is a crucial receptor on natural killer (NK) cells that plays a pivotal role in recognizing and eliminating infected or transformed cells. Its activation leads to the release of cytotoxic granules, ultimately mediating the destruction of target cells. Understanding the function and regulation of NCR1 is essential for elucidating the mechanisms underlying NK cell activity and may offer insights into developing novel immunotherapies for infectious diseases and cancer.
Product Name:
NCR1 Rabbit Polyclonal Antibody
SKU:
CAB14499
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 151-303 of human NCR1 (NP_001138929.2).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
34kDa
Observed MW:
34kDa
Predicted to be involved in cellular defense response; regulation of natural killer cell mediated cytotoxicity; and signal transduction. Predicted to act upstream of or within defense response to virus and detection of virus. Predicted to be located in cell surface. Predicted to be part of SWI/SNF complex. Predicted to be active in plasma membrane. Biomarker of acquired immunodeficiency syndrome; anogenital venereal wart; hepatitis C; and lymphoproliferative syndrome.
Purification Method:
Affinity purification
Gene ID:
9437
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Rat spleen, using NCR1 antibody (CAB14499) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
