The NCOR2 Polyclonal Antibody (CAB8388) is a crucial tool for researchers studying the NCOR2 protein, a corepressor involved in transcriptional regulation and gene expression. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot assays. By binding specifically to NCOR2, this antibody facilitates the detection and exploration of NCOR2 protein levels in various cell types, making it an invaluable resource for investigations in molecular biology and cancer research.NCOR2, also known as nuclear receptor corepressor 2, plays a key role in mediating transcriptional repression and influencing diverse biological processes, including cell growth and differentiation.
Dysregulation of NCOR2 has been linked to a variety of diseases, making it a promising target for therapeutic interventions in conditions such as cancer, metabolic disorders, and neurological diseases. Unraveling the functions of NCOR2 is essential for advancing our understanding of disease mechanisms and developing novel treatment strategies.
Product Name:
NCOR2 Rabbit Polyclonal Antibody
SKU:
CAB8388
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human NCOR2 (NP_006303.4).
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
9612
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NCOR2 Rabbit pAb (CAB8388) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
