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NCOA7 Monoclonal Antibody

SKU:
CAB23949
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
$167 - $635
Frequently bought together:

Description

NCOA7 Monoclonal Antibody (CAB23949)

The NCOA7 Monoclonal Antibody is a valuable tool for research involving NCOA7, a nuclear receptor coactivator known for its role in gene transcription and cellular signaling pathways. This antibody, generated using hybridoma technology, specifically targets NCOA7 in human samples and is validated for use in various applications, including immunofluorescence and flow cytometry.NCOA7, also known as steroid receptor coactivator 3 (SRC-3), is a key player in the regulation of gene expression, particularly in hormone-responsive tissues such as the breast and prostate.

Its involvement in hormone receptor signaling makes it a potential target for studies on endocrine-related diseases, including breast and prostate cancer. By detecting and quantifying NCOA7 levels, researchers can gain insights into its function and potential therapeutic implications in these disease contexts.Overall, the NCOA7 Monoclonal Antibody is a valuable resource for researchers looking to explore the role of NCOA7 in gene regulation and hormone signaling pathways, paving the way for advancements in cancer research and endocrine-related disorders.

Product Name:NCOA7 Monoclonal Antibody
Product Code:CAB23949
Reactivity:Human, Mouse
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC61925
Reactivity:Human, Mouse
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:500-1:1000
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:Mouse brain
Cellular Location:Nucleus

Nuclear receptors for steroids, thyroid hormones and retinoic acids are ligand-dependent transcription factors that activate transcription through specific DNA binding sites in their target genes. NCoA-7 (nuclear receptor coactivator 7), also known as ESNA1 or ERAP140, is a 942 amino acid nuclear protein that enhances nuclear receptor transcriptional activities and coactivates several nuclear receptors including PPARG, ESR1, THRB and RARA. Highly expressed in brain and weakly expressed in pancreas, bladder, ovary, spinal cord, prostate, mammary gland, ovary, uterus and stomach, NCoA-7 is a member of the OXR1 family and contains one LysM repeat and a TLD domain. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human NCOA7 protein.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 777-942 of human NCOA7(NP_861447.3).
Sequence:LRPHS ALLEN MHIEQ LARRL PARVQ GYPWR LAYST LEHGT SLKTL YRKSA SLDSP VLLVI KDMDN QIFGA YATHP FKFSD HYYGT GETFL YTFSP HFKVF KWSGE NSYFI NGDIS SLELG GGGGR FGLWL DADLY HGRSN SCSTF NNDIL SKKED FIVQD LEVWA FD
Synonyms:NCOA7, ERAP140, ESNA1, NCOA7-AS, Nbla00052, Nbla10993, TLDC4, dJ187J11.3, nuclear receptor coactivator 7
Calculated MW:12kDa/25kDa/28kDa/33kDa/92-106kDa
Observed MW:120-140kDa

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