The NCOA1 Polyclonal Antibody (CAB1128) is a vital tool for research involving NCOA1, a nuclear receptor coactivator known for its role in gene transcription and regulation. This antibody, generated in rabbits, shows high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to the NCOA1 protein, this antibody facilitates the detection and analysis of NCOA1 in various cell types, making it perfect for studies in molecular biology and cancer research.
NCOA1, also referred to as steroid receptor coactivator 1, plays a crucial role in mediating hormone signaling and gene expression, making it a key player in various cellular processes. Its involvement in transcriptional regulation makes it a promising target for studying diseases like cancer, metabolic disorders, and hormone-related conditions. Understanding the functions of NCOA1 is essential for advancing our knowledge of disease mechanisms and developing targeted therapies to treat them effectively.
Product Name:
NCOA1 Rabbit Polyclonal Antibody
SKU:
CAB1128
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 720-980 of human NCOA1 (NP_003734.3).
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
8648
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NCOA1 Rabbit pAb (CAB1128) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
