The NCLN Antibody (PAC063831) is a highly specific polyclonal antibody designed for research involving NCLN, a protein that plays a critical role in cellular processes. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in Western blot applications. By binding to the NCLN protein, this antibody enables accurate detection and analysis in various cell types, making it an ideal tool for studies in cell biology and disease mechanisms.NCLN, also known as Nicalin, is involved in regulating protein trafficking and plays a role in maintaining cellular homeostasis.
Its function in cellular processes makes it a valuable target for research into various diseases, including neurodegenerative disorders, metabolic diseases, and cancer. Understanding the role of NCLN is crucial for developing new therapies that target these diseases at the molecular level. Overall, the NCLN Antibody is a valuable tool for researchers looking to investigate the role of NCLN in cellular processes and disease pathways, providing crucial insights that could lead to the development of novel therapeutic strategies.
IHC image of PACO63831 diluted at 1:100 and staining in paraffin-embedded human pancreatic cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning.
Synonyms:
Nicalin (Nicastrin-like protein), NCLN
UniProt Protein Function:
NCLN: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. Belongs to the nicastrin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.3Cellular Component: endoplasmic reticulum membrane; membrane; integral to membraneMolecular Function: protein bindingBiological Process: regulation of signal transduction
