The NCBP2 Polyclonal Antibody (CAB7293) is a valuable tool for researchers studying NCBP2, a protein involved in ribosome biogenesis and RNA metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been specifically validated for use in Western blot applications. By binding to the NCBP2 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in molecular biology and cancer research.NCBP2, also known as Nuclear cap-binding protein subunit 2, plays a crucial role in the regulation of gene expression by facilitating the post-transcriptional processing of RNA molecules.
Its involvement in ribosome assembly highlights its importance in protein synthesis and cellular growth. Research on NCBP2 is essential for understanding its function in normal cellular processes as well as its potential role in diseases like cancer, where dysregulation of ribosome biogenesis can lead to abnormal cell proliferation. Utilizing the NCBP2 Polyclonal Antibody in studies can provide valuable insights into the mechanisms underlying ribosome biogenesis and RNA metabolism, ultimately contributing to the development of novel therapeutic strategies for cancer and other diseases linked to aberrant protein synthesis.
Product Name:
NCBP2 Rabbit Polyclonal Antibody
SKU:
CAB7293
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-156 of human NCBP2 (NP_031388.2).
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5' cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3'-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
22916
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of U-251MG, using NCBP2 Rabbit pAb (CAB7293) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
