The NcapG2 Polyclonal Antibody (PACO4661) is a valuable tool for researchers investigating NcapG2, a protein involved in chromosome condensation and segregation during cell division. This antibody, produced in rabbits, is highly specific for detecting NcapG2 in human samples and has been validated for use in Western blotting applications. By binding to the NcapG2 protein, this antibody enables accurate detection and analysis in various cell types, making it essential for studies related to cell division, mitosis, and chromosome organization.NcapG2 is a key player in ensuring the proper organization and segregation of chromosomes during cell division, making it a crucial target for research in areas such as cancer biology and developmental biology.
Understanding the function of NcapG2 can provide insights into the mechanisms underlying chromosome segregation errors that contribute to genetic abnormalities and diseases like cancer. By studying NcapG2, researchers can uncover potential therapeutic targets for treating conditions related to aberrant cell division and chromosome instability.
Antibody Name:
NCAPG2 Antibody
Antibody SKU:
PACO04661
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human hCAP-G2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
NCAPG2; LUZP5; Condensin-2 complex subunit G2; Chromosome-associated protein G2; CAP-G2; hCAP-G2; Leucine zipper protein 5; Non-SMC condensin II complex subunit G2
UniProt Protein Function:
LUZP5: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 7q36.3Cellular Component: membrane; nucleoplasmMolecular Function: methylated histone residue binding; protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
