The NCAPD3 Polyclonal Antibody (PAC010752) is a reliable tool for studying NCAPD3, a key protein involved in cell division and chromosome organization. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the NCAPD3 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for researchers in the fields of cell biology and cancer research.NCAPD3, also known as non-SMC condensin II complex subunit D3, plays a crucial role in chromatin condensation and segregation during mitosis, ensuring proper cell division and genomic stability.
Its involvement in these processes makes NCAPD3 a potential target for studying diseases such as cancer, where aberrant cell division can lead to tumorigenesis. By investigating the function of NCAPD3, researchers can gain valuable insights into the mechanisms underlying cell proliferation and potentially uncover new therapeutic strategies for treating cancer and other proliferative disorders.
non-SMC condensin II complex, subunit D3;NCAPD3;CAP-D3;FLJ42888;KIAA0056;MGC104671;hCAP-D3;hHCP-6;hcp-6 ;
UniProt Protein Function:
NCAPD3: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 11q25Cellular Component: membrane; nucleoplasmMolecular Function: chromatin binding; methylated histone residue binding; protein bindingBiological Process: chromosome separation; meiotic chromosome condensation; mitotic chromosome condensation
UniProt Protein Details:
NCBI Summary:
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008]
