The NCAM1 Polyclonal Antibody (CAB7913) is a valuable tool for research involving the Neural Cell Adhesion Molecule 1 (NCAM1), a cell surface protein that plays important roles in cell adhesion, migration, and signal transduction. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in applications such as immunofluorescence, immunohistochemistry, and Western blotting.NCAM1 is known to be involved in various biological processes, including neuronal development, synaptic plasticity, and immune response modulation. Its expression has been linked to diseases like cancer, neurodevelopmental disorders, and neurodegenerative diseases.
By targeting NCAM1 with this polyclonal antibody, researchers can investigate its function and potential as a therapeutic target in these diseases.This antibody provides researchers with a reliable tool for detecting and studying NCAM1 in different cell types and tissues. Its specificity and sensitivity make it ideal for a wide range of experimental settings, making it a valuable asset for studies in neuroscience, cancer biology, and immunology.
Product Name:
NCAM1/CD56 Rabbit Polyclonal Antibody
SKU:
CAB7913
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 759-858 of human NCAM1 / CD56 (NP_851996.2).
Cell membrane, GPI-anchor, Lipid-anchor, Secreted, Single-pass type I membrane protein.
Calculated MW:
95kDa
Observed MW:
120-220kDa/
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Purification Method:
Affinity purification
Gene ID:
4684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using NCAM1 / CD56 Rabbit pAb (CAB7913) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
