The NCAM1 Polyclonal Antibody (CAB0393) is a valuable tool for researchers studying NCAM1, a cell adhesion molecule known for its role in cell-cell interactions and neural development. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it ideal for use in Western blot applications.NCAM1, also referred to as neural cell adhesion molecule 1, is involved in processes such as cell migration, neurite outgrowth, and synaptic plasticity. Its expression has been linked to various pathologies, including neurodevelopmental disorders and certain types of cancer.
By targeting NCAM1 with this antibody, researchers can detect and analyze its presence in different cell types, enabling further investigation into its function and potential therapeutic implications.With its reliability and versatility, the NCAM1 Polyclonal Antibody (CAB0393) is a valuable asset for studies in neuroscience, developmental biology, and cancer research. By gaining a better understanding of NCAM1 and its associated pathways, researchers can uncover new insights into disease mechanisms and potentially develop targeted therapies in the future.
Product Name:
NCAM1/CD56 Rabbit Polyclonal Antibody
SKU:
CAB0393
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 759-858 of human NCAM1 / CD56 (NP_851996.2).
Cell membrane, GPI-anchor, Lipid-anchor, Secreted, Single-pass type I membrane protein.
Calculated MW:
95kDa
Observed MW:
120kDa/140kDa/180kDa
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms.
Purification Method:
Affinity purification
Gene ID:
4684
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using NCAM1 / CD56 Rabbit pAb (CAB0393).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
