The Neurocalcin Delta Polyclonal Antibody (CAB8000) is a valuable tool for researchers studying neurocalcin delta, a calcium-binding protein essential for neuronal function. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the neurocalcin delta protein, researchers can effectively analyze its expression and function in various neuronal cell types.Neurocalcin delta is known for its role in calcium signaling within neurons, influencing processes such as neurotransmitter release and synaptic plasticity.
Understanding the function of neurocalcin delta is crucial for unraveling its contribution to neurological disorders such as Alzheimer's disease, epilepsy, and Parkinson's disease. By utilizing the Neurocalcin Delta Polyclonal Antibody, researchers can delve deeper into the mechanisms underlying these conditions and potentially identify new therapeutic targets.
Product Name:
NCALD Rabbit Polyclonal Antibody
SKU:
CAB8000
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human NCALD (NP_114430.2).
clathrin coat of trans-Golgi network vesicle, cytosol
Calculated MW:
22kDa
Observed MW:
22kDa
This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
83988
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NCALD antibody (CAB8000) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
