NBS1/NBN Polyclonal Antibody (CAB21501)
- SKU:
- CAB21501
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- IF
Frequently bought together:
Description
Product Name: | NBS1/NBN Polyclonal Antibody |
SKU: | CAB21501 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 650-750 of human NBS1/NBN (NP_002476.2). |
Sequence: | LPKK LLLT EFRS LVIK NSTS RNPS GIND DYGQ LKNF KKFK KVTY PGAG KLPH IIGG SDLI AHHA RKNT ELEE WLRQ EMEV QNQH AKEE SLAD DLFR YNPY L |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | ATV; NBS; P95; NBS1; AT-V1; AT-V2; NBS1/NBN |
Positive Sample: | Jurkat,HeLa,MCF7,Mouse heart,Rat kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, PML body, telomere. |
Calculated MW: | 85kDa |
Observed MW: | Refer to figures |
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Purification Method: | Affinity purification |
Gene ID: | 4683 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |