The NBS1/NBN Polyclonal Antibody is a valuable tool for research involving the NBS1/NBN protein, which plays a crucial role in DNA repair and maintaining genomic stability. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it an ideal choice for studies in molecular biology and cancer research. Validated for use in Western blot applications, the NBS1/NBN Polyclonal Antibody enables the detection and analysis of the NBS1/NBN protein in various cell types. Its high sensitivity and specificity allow for accurate and reliable results, making it a valuable asset for researchers studying the mechanisms of DNA repair and genome maintenance.
With its ability to target and detect the NBS1/NBN protein, this polyclonal antibody is essential for gaining insights into how disruptions in DNA repair pathways can lead to genomic instability and contribute to the development of cancer. By understanding the role of NBS1/NBN in these processes, researchers can identify potential therapeutic targets for the treatment of cancer and other diseases related to DNA damage.
Product Name:
NBS1/NBN Polyclonal Antibody
SKU:
CAB21501
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 650-750 of human NBS1/NBN (NP_002476.2).
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Purification Method:
Affinity purification
Gene ID:
4683
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NBS1/NBN Rabbit pAb (CAB21501) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
