The NBP1-52085 Monoclonal Antibody (PACO22464) is a versatile tool for researchers studying NBPF7, a neuroblastoma breakpoint family member involved in neurogenesis and tumor development. This antibody, produced using hybridoma technology, demonstrates high specificity and sensitivity when detecting NBPF7 in human samples, making it ideal for immunohistochemistry and flow cytometry applications. NBPF7, a member of the NBPF gene family, is known for its role in neural development and has been implicated in various cancers, including neuroblastoma.
By targeting NBPF7, researchers can gain insights into its function and potential as a therapeutic target in neuroblastoma and other related malignancies. This antibody provides a valuable tool for studying the expression and localization of NBPF7 in different cell types, offering new opportunities for research in cancer biology and developmental neurobiology.
Antibody Name:
NBPF7 Antibody (PACO22464)
Antibody SKU:
PACO22464
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human NBPF7.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells and HT-29 cells, using NBPF7 antibody.
Background:
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes.
Synonyms:
Neuroblastoma breakpoint family member 7; NBPF7;
UniProt Protein Function:
NBPF7: Belongs to the NBPF familyChromosomal Location of Human Ortholog: 1p12Cellular Component: cytoplasm
UniProt Protein Details:
NCBI Summary:
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, cognitive disability, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Mar 2013]
