The NBPF3 Polyclonal Antibody (PAC041046) is a valuable tool for researchers studying NBPF3, a protein associated with neuroblastoma breakpoint family member 3. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting NBPF3 in human samples, making it an ideal choice for Western blot applications. By binding to the NBPF3 protein, this antibody enables accurate analysis and visualization of NBPF3 expression in a variety of cell types, facilitating research in neuroblastoma and other related fields.NBPF3 is a protein that plays a role in the regulation of cell growth and proliferation, making it a key target for investigation in cancer research and developmental biology.
Its involvement in neuroblastoma, a type of cancer that affects nerve tissue, highlights its potential as a therapeutic target for the treatment of this disease. By studying the function and expression of NBPF3, researchers can gain insights into the molecular mechanisms underlying neuroblastoma progression and potentially identify novel therapeutic strategies for combating this form of cancer.
Western blot. All lanes: NBPF3 antibody at 1.2µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: HT29 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 73, 68, 72, 33, 66 kDa. Observed band size: 73 kDa.
Immunohistochemistry of paraffin-embedded human colon tissue using PACO41046 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO41046 at dilution of 1:100.
Background:
positive regulation of protein targeting to mitochondrion
Synonyms:
Neuroblastoma breakpoint family member 3 (Protein AE2) (Protein SHIIIa4), NBPF3
UniProt Protein Function:
NBPF3: Belongs to the NBPF family. 4 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 1p36.12Cellular Component: cytoplasm
UniProt Protein Details:
NCBI Summary:
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. DUF1220 copy number variations in human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Feb 2013]
