The NBPF1-NBPF9-NBPF10-NBPF12-NBPF14-NBPF15-NBPF16-NBPF20 Antibody (PAC022462) is a polyclonal antibody specifically designed for research involving the NBPF gene family. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.The NBPF gene family consists of multiple members, including NBPF1, NBPF9, NBPF10, NBPF12, NBPF14, NBPF15, NBPF16, and NBPF20, which play important roles in various cellular processes. This antibody specifically binds to proteins encoded by these genes, enabling researchers to detect and analyze their expression in different cell types.
Studies have shown that members of the NBPF gene family are involved in diverse biological functions, such as cell growth, proliferation, and differentiation. Understanding the roles of these genes can provide valuable insights into various disease processes, including cancer and neurological disorders.Overall, the NBPF1-NBPF9-NBPF10-NBPF12-NBPF14-NBPF15-NBPF16-NBPF20 Antibody is a valuable tool for researchers interested in exploring the functions of the NBPF gene family and its implications in health and disease.
Synthesized peptide derived from internal of human NBPF1/9/10/12/14/15/16/20.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from JK cells, using NBPF1/9/10/12/14/15/16/20 antibody.
Background:
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes.
Gregory S.G., Nature 441:315-321(2006). Mei G., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
Synonyms:
NBPFC; neuroblastoma breakpoint family; 12;
UniProt Protein Function:
NBPF12: Belongs to the NBPF family.Chromosomal Location of Human Ortholog: 1q21Cellular Component: cytoplasm
UniProt Protein Details:
NCBI Summary:
This gene is a member of the neuroblastoma breakpoint family (NBPF) which consists of dozens of recently duplicated genes primarily located in segmental duplications on human chromosome 1. This gene family has experienced its greatest expansion within the human lineage and has expanded, to a lesser extent, among primates in general. Members of this gene family are characterized by tandemly repeated copies of DUF1220 protein domains. Gene copy number variations in the human chromosomal region 1q21.1, where most DUF1220 domains are located, have been implicated in a number of developmental and neurogenetic diseases such as microcephaly, macrocephaly, autism, schizophrenia, mental retardation, congenital heart disease, neuroblastoma, and congenital kidney and urinary tract anomalies. Altered expression of some gene family members is associated with several types of cancer. This gene family contains numerous pseudogenes. [provided by RefSeq, Apr 2013]
