The NBL1 Polyclonal Antibody (PACO16735) is a versatile tool for researchers studying the NBL1 protein, a key regulator of cell growth and development. This antibody, produced in rabbits, shows high specificity and sensitivity towards human samples, making it ideal for Western blot and immunohistochemistry applications.NBL1, also known as neuroblastoma suppressor of tumorigenicity 1, is involved in inhibiting tumor growth and metastasis in various cancers, making it a promising target for cancer research. By binding to the NBL1 protein, this antibody allows for the detection and analysis of NBL1 expression in different cell types, providing valuable insights into its role in tumorigenesis and potential therapeutic interventions.
With its ability to accurately detect NBL1 in biological samples, the PACO16735 antibody is a valuable asset for researchers in oncology and cell biology seeking to deepen their understanding of NBL1's function and explore its implications for cancer treatment and drug development.
Antibody Name:
NBL1 Antibody (PACO16735)
Antibody SKU:
PACO16735
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human NBL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO16735(NBL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development.
Synonyms:
neuroblastoma 1, DAN family BMP antagonist
UniProt Protein Function:
NBL1 iso2: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Tumor suppressor; Secreted
Chromosomal Location of Human Ortholog: 1p36.13
Cellular Component: extracellular space
Molecular Function:morphogen activity; protein homodimerization activity
Biological Process: nervous system development; determination of dorsal identity; positive regulation of neuron differentiation; neurite morphogenesis; negative regulation of BMP signaling pathway
NCBI Summary:
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
neuroblastoma suppressor of tumorigenicity 1 isoform 2
NCBI Synonym Full Names:
neuroblastoma 1, DAN family BMP antagonist
NCBI Official Symbol:
NBL1Â Â
NCBI Official Synonym Symbols:
NB; DAN; NO3; DAND1; D1S1733EÂ Â
NCBI Protein Information:
neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1
UniProt Protein Name:
Neuroblastoma suppressor of tumorigenicity 1
UniProt Synonym Protein Names:
DAN domain family member 1; Protein N03; Zinc finger protein DAN
