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NBL1 Antibody (PACO00684)

SKU:
PACO00684
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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NBL1 Antibody (PACO00684)

The NBL1 Polyclonal Antibody (PACO00684) is a powerful tool for researchers studying NBL1, a secreted glycoprotein that plays a crucial role in the regulation of cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications.NBL1 is known to be involved in various cellular processes, including cell adhesion, migration, and proliferation. Dysregulation of NBL1 expression has been linked to tumorigenesis and metastasis in several types of cancer, making it a promising target for cancer research.

The NBL1 Polyclonal Antibody can help researchers detect and analyze NBL1 protein levels in different cell types, providing valuable insights into its functions and potential therapeutic applications.By using the NBL1 Polyclonal Antibody in their studies, researchers can deepen their understanding of the molecular mechanisms underlying cancer development and progression. This antibody is essential for investigating the role of NBL1 in cancer biology and identifying novel strategies for targeted cancer therapy.

Antibody Name:NBL1 Antibody
Antibody SKU:PACO00684
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the C-terminal region of human DAN.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:NBL1; DAN; DAND1; Neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; Protein N03; Zinc finger protein DAN
UniProt Protein Function:NBL1 iso2: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Tumor suppressor; Secreted

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: extracellular space

Molecular Function:morphogen activity; protein homodimerization activity

Biological Process: nervous system development; determination of dorsal identity; positive regulation of neuron differentiation; neurite morphogenesis; negative regulation of BMP signaling pathway

NCBI Summary:This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
UniProt Code:P41271
NCBI GenInfo Identifier:323276675
NCBI Gene ID:4681
NCBI Accession:NP_001191013.1
UniProt Secondary Accession:P41271,Q5TGZ2, Q5U0N4, Q96L68, A3KFI7,
UniProt Related Accession:P41271
Molecular Weight:19,277 Da
NCBI Full Name:neuroblastoma suppressor of tumorigenicity 1 isoform 2
NCBI Synonym Full Names:neuroblastoma 1, DAN family BMP antagonist
NCBI Official Symbol:NBL1  
NCBI Official Synonym Symbols:NB; DAN; NO3; DAND1; D1S1733E  
NCBI Protein Information:neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1
UniProt Protein Name:Neuroblastoma suppressor of tumorigenicity 1
UniProt Synonym Protein Names:DAN domain family member 1; Protein N03; Zinc finger protein DAN
Protein Family:D-aminoacylase
UniProt Gene Name:NBL1  
UniProt Entry Name:NBL1_HUMAN

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