The NAV1 Polyclonal Antibody (PACO10743) is a powerful tool for researchers studying NAV1, a key protein involved in neuronal signaling and ion channel function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blot and immunofluorescence.NAV1, also known as voltage-gated sodium channel Nav1, plays a critical role in the propagation of action potentials in neurons. Dysregulation of NAV1 has been implicated in a range of neurological disorders, including epilepsy, neuropathic pain, and movement disorders.
By targeting NAV1 with this antibody, researchers can gain valuable insights into the function and dysfunction of this protein in health and disease.Whether studying basic neuronal physiology or investigating the mechanisms underlying neurological disorders, the NAV1 Polyclonal Antibody (PACO10743) is a versatile tool that enables accurate detection and analysis of NAV1 protein expression in various cell types. Its reliability and specificity make it a valuable asset for neuroscientists and researchers in related fields.
NAV1: May be involved in neuronal migration. Belongs to the Nav/unc-53 family. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Motility/polarity/chemotaxis; CytoskeletalChromosomal Location of Human Ortholog: 1q32.3Cellular Component: cytoplasm; microtubuleMolecular Function: protein bindingBiological Process: microtubule bundle formation; neuron migration
UniProt Protein Details:
NCBI Summary:
This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known, but it is thought to play a role in in neuronal development and regeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]
