The NAT2 Polyclonal Antibody (CAB12766) is a powerful tool for researchers studying NAT2, a key enzyme involved in the metabolism of various drugs and environmental chemicals. This antibody, produced in rabbits, is highly specific towards human samples and has been validated for Western blot applications. By binding to the NAT2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for research in pharmacology, toxicology, and personalized medicine.NAT2, also known as N-acetyltransferase 2, plays a crucial role in the biotransformation of xenobiotics, which are foreign substances that enter the body.
Variations in the activity of NAT2 have been linked to differences in drug metabolism and susceptibility to certain diseases. By studying NAT2 function, researchers can gain insights into individual responses to medications and potentially uncover new strategies for personalized treatment approaches.The NAT2 Polyclonal Antibody is a valuable resource for investigating the role of NAT2 in drug metabolism, toxicity, and disease susceptibility. Its high specificity and reactivity make it a reliable choice for researchers seeking to advance our understanding of personalized medicine and improve patient outcomes.
Product Name:
NAT2 Rabbit Polyclonal Antibody
SKU:
CAB12766
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 171-290 of human NAT2 (NP_000006.2).
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second polymorphic arylamine N-acetyltransferase gene (NAT1), is located near this gene (NAT2).
Purification Method:
Affinity purification
Gene ID:
10
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NAT2 Rabbit pAb (CAB12766) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
