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NARFL Antibody (PACO13531)

SKU:
PACO13531
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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NARFL Antibody (PACO13531)

The NARFL Polyclonal Antibody (PAC013531) is a specialized tool for researchers studying the NARFL protein, an essential component of the iron-sulfur (Fe-S) cluster assembly pathway in mitochondria. This antibody is produced in rabbits and is highly specific to human samples, making it a reliable choice for Western blot applications. By binding to NARFL, this antibody allows for accurate detection and analysis of the protein in various cell types, making it a valuable tool for studies in mitochondrial biology and related diseases.NARFL is a crucial player in maintaining mitochondrial function and energy production by facilitating the assembly of Fe-S clusters, which are essential for the activity of numerous mitochondrial enzymes.

Dysregulation of NARFL has been implicated in mitochondrial diseases and metabolic disorders, highlighting its importance in cellular health. By elucidating the role of NARFL, researchers can gain insights into mitochondrial dysfunction and potentially identify new therapeutic targets for diseases associated with mitochondrial impairment.

Antibody Name:NARFL Antibody (PACO13531)
Antibody SKU:PACO13531
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human NARFL-Specific
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:nuclear prelamin A recognition factor-like;NARFL;FLJ21988;HPRN;IOP1;LET1L;PRN ;
UniProt Protein Function:NARFL: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. Belongs to the NARF family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 16p13.3

Biological Process: iron-sulfur cluster assembly; oxygen homeostasis; regulation of transcription, DNA-dependent; response to hypoxia

UniProt Code:Q9H6Q4
NCBI GenInfo Identifier:74733617
NCBI Gene ID:64428
NCBI Accession:Q9H6Q4.1
UniProt Secondary Accession:Q9H6Q4,Q53GC6, Q96S10, Q9H6J8, A1L385, B3KTJ3,
UniProt Related Accession:Q9H6Q4
Molecular Weight:42,010 Da
NCBI Full Name:Cytosolic Fe-S cluster assembly factor NARFL
NCBI Synonym Full Names:nuclear prelamin A recognition factor like
NCBI Official Symbol:NARFL  
NCBI Official Synonym Symbols:PRN; HPRN; IOP1; NAR1; LET1L  
NCBI Protein Information:cytosolic Fe-S cluster assembly factor NARFL
UniProt Protein Name:Cytosolic Fe-S cluster assembly factor NARFL
UniProt Synonym Protein Names:Iron-only hydrogenase-like protein 1; IOP1; Nuclear prelamin A recognition factor-like protein; Protein related to Narf
Protein Family:Cytosolic Fe-S cluster assembly factor
UniProt Gene Name:NARFL  
UniProt Entry Name:NARFL_HUMAN

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