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NARFL Antibody (PACO01138)

SKU:
PACO01138
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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NARFL Antibody (PACO01138)

The NARFL Polyclonal Antibody (PACO01138) is a crucial tool for researchers studying NARFL, a protein involved in mitochondrial iron-sulfur cluster (Fe-S) biogenesis. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the NARFL protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in the fields of biochemistry and cellular metabolism.NARFL is known for its role in the assembly and transfer of Fe-S clusters in mitochondria, essential for the function of numerous proteins involved in energy production and redox homeostasis.

Dysregulation of NARFL activity has been associated with various diseases, including mitochondrial disorders and neurodegenerative conditions. Therefore, studying the function of NARFL is crucial for advancing our understanding of mitochondrial biology and developing potential therapies for related disorders.In summary, the NARFL Polyclonal Antibody is a valuable tool for researchers interested in exploring the intricate mechanisms of mitochondrial Fe-S cluster biogenesis and its implications for human health and disease. Its high specificity and sensitivity make it an indispensable asset for studies aimed at unraveling the complex roles of NARFL in cellular metabolism and mitochondrial function.

Antibody Name:NARFL Antibody
Antibody SKU:PACO01138
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human
Immunogen:synthesized peptide derived from the C-terminal region of human NARFL.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:NARFL; PRN; Cytosolic Fe-S cluster assembly factor NARFL; Iron-only hydrogenase-like protein 1; IOP1; Nuclear prelamin A recognition factor-like protein; Protein related to Narf
UniProt Protein Function:NARFL: Component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect. Belongs to the NARF family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 16p13.3

Biological Process: iron-sulfur cluster assembly; oxygen homeostasis; regulation of transcription, DNA-dependent; response to hypoxia

UniProt Code:Q9H6Q4
NCBI GenInfo Identifier:74733617
NCBI Gene ID:64428
NCBI Accession:Q9H6Q4.1
UniProt Secondary Accession:Q9H6Q4,Q53GC6, Q96S10, Q9H6J8, A1L385, B3KTJ3,
UniProt Related Accession:Q9H6Q4
Molecular Weight:42,010 Da
NCBI Full Name:Cytosolic Fe-S cluster assembly factor NARFL
NCBI Synonym Full Names:nuclear prelamin A recognition factor like
NCBI Official Symbol:NARFL  
NCBI Official Synonym Symbols:PRN; HPRN; IOP1; NAR1; LET1L  
NCBI Protein Information:cytosolic Fe-S cluster assembly factor NARFL
UniProt Protein Name:Cytosolic Fe-S cluster assembly factor NARFL
UniProt Synonym Protein Names:Iron-only hydrogenase-like protein 1; IOP1; Nuclear prelamin A recognition factor-like protein; Protein related to Narf
Protein Family:Cytosolic Fe-S cluster assembly factor
UniProt Gene Name:NARFL  
UniProt Entry Name:NARFL_HUMAN

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