NARF Antibody (PACO51738)
- SKU:
- PACO51738
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
NARF Antibody (PACO51738)
The NARF Polyclonal Antibody (PACO51738) is a valuable tool for researchers studying the NARF protein, which is involved in various cellular processes, including mitochondrial function and metabolism. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.NARF, also known as Nucleolar and coiled-body phosphoprotein, plays a crucial role in maintaining mitochondrial homeostasis and has been implicated in diseases such as cancer and neurodegenerative disorders.
By targeting the NARF protein, researchers can gain insights into the molecular mechanisms underlying these conditions and develop potential therapeutic interventions.With its high reactivity and specificity, the NARF Polyclonal Antibody is an essential tool for researchers in the fields of cell biology, biochemistry, and cancer research. Its ability to detect and analyze NARF in various cell types makes it a valuable asset for studying the role of this protein in health and disease.
| Antibody Name: | NARF Antibody (PACO51738) |
| Antibody SKU: | PACO51738 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Nuclear prelamin A recognition factor protein (10-41AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: A549 whole cell lysate, MCF-7 whole cell lysate, Mouse kidney tissue, Mouse skeletal muscle tissue. All lanes: NARF antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 52, 57, 46, 45 kDa. Observed band size: 52 kDa.. |
 | Immunofluorescent analysis of Hela cells using PACO51738 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | lamin filament, nuclear lamina, nuclear lumen, lamin binding |
| Synonyms: | Nuclear prelamin A recognition factor (Iron-only hydrogenase-like protein 2) (IOP2), NARF |
| UniProt Protein Function: | NARF: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 17q25.3Cellular Component: lamin filament; nuclear lamina; nuclear lumenMolecular Function: lamin binding |
| UniProt Protein Details: | |
| NCBI Summary: | Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHQ1 |
| NCBI GenInfo Identifier: | 74735021 |
| NCBI Gene ID: | 26502 |
| NCBI Accession: | Q9UHQ1.1 |
| UniProt Secondary Accession: | Q9UHQ1,Q96AY9, Q9BWC6, A6NCJ3, B3KPX2, K4DI98 |
| UniProt Related Accession: | Q9UHQ1 |
| Molecular Weight: | 44,681 Da |
| NCBI Full Name: | Nuclear prelamin A recognition factor |
| NCBI Synonym Full Names: | nuclear prelamin A recognition factor |
| NCBI Official Symbol: | NARFÂ Â |
| NCBI Official Synonym Symbols: | IOP2Â Â |
| NCBI Protein Information: | nuclear prelamin A recognition factor |
| UniProt Protein Name: | Nuclear prelamin A recognition factor |
| UniProt Synonym Protein Names: | Iron-only hydrogenase-like protein 2; IOP2 |
| Protein Family: | Nuclear prelamin A recognition factor |
| UniProt Gene Name: | NARFÂ Â |
| UniProt Entry Name: | NARF_HUMAN |
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