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NARF Antibody (PACO10732)

SKU:
PACO10732
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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NARF Antibody (PACO10732)

The NARF Polyclonal Antibody (PACO10732) is a valuable tool for researchers studying the NARF protein, an essential component of mitochondrial function and energy metabolism. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the NARF protein, this antibody allows for the detection and analysis of NARF in a variety of cell types, making it an ideal choice for studies in mitochondrial biology and metabolic disorders.NARF, also known as the NADH-quinone oxidoreductase chaperone, plays a crucial role in the assembly and function of complex I in the mitochondrial electron transport chain.

Dysregulation of NARF has been linked to various mitochondrial disorders and metabolic diseases, making it a promising target for research in areas such as neurodegenerative diseases, metabolic syndromes, and aging. By understanding the function and regulation of NARF, researchers can gain insights into the mechanisms underlying these conditions and develop potential therapeutic interventions.

Antibody Name:NARF Antibody (PACO10732)
Antibody SKU:PACO10732
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human NARF
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:nuclear prelamin A recognition factor;NARF;DKFZp434G0420;FLJ10067;IOP2 ;
UniProt Protein Function:NARF: Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]Chromosomal Location of Human Ortholog: 17q25.3Cellular Component: lamin filament; nuclear lamina; nuclear lumenMolecular Function: lamin binding
UniProt Protein Details:
NCBI Summary:Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UHQ1
NCBI GenInfo Identifier:74735021
NCBI Gene ID:26502
NCBI Accession:Q9UHQ1.1
UniProt Secondary Accession:Q9UHQ1,Q96AY9, Q9BWC6, A6NCJ3, B3KPX2, K4DI98
UniProt Related Accession:Q9UHQ1
Molecular Weight:44,681 Da
NCBI Full Name:Nuclear prelamin A recognition factor
NCBI Synonym Full Names:nuclear prelamin A recognition factor
NCBI Official Symbol:NARF  
NCBI Official Synonym Symbols:IOP2  
NCBI Protein Information:nuclear prelamin A recognition factor
UniProt Protein Name:Nuclear prelamin A recognition factor
UniProt Synonym Protein Names:Iron-only hydrogenase-like protein 2; IOP2
Protein Family:Nuclear prelamin A recognition factor
UniProt Gene Name:NARF  
UniProt Entry Name:NARF_HUMAN

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