The Napsin-A Polyclonal Antibody (CAB5594) is a vital tool for research involving Napsin-A, an aspartic protease implicated in the development and differentiation of lung and kidney cells. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot and immunohistochemistry applications.Napsin-A, also known as Napsin A Cleaves preproteins Into smaller peptides A, is crucial for the maturation of surfactant protein in the lungs, making it an important marker for lung adenocarcinoma and renal cell carcinoma.
Studies utilizing this antibody can provide valuable insights into the role of Napsin-A in these diseases, aiding in diagnosis and treatment strategies.The ability of the Napsin-A Polyclonal Antibody to specifically bind to the Napsin-A protein enables precise detection and analysis in various tissue samples, making it an ideal choice for researchers in the fields of oncology and nephrology. By understanding the function and expression of Napsin-A, new therapeutic avenues may be discovered for targeting these types of cancer effectively.
Product Name:
NAPSA Rabbit Polyclonal Antibody
SKU:
CAB5594
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 321-420 of human NAPSA (NP_004842.1).
This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein is proteolytically processed to generate an activation peptide and the mature protease. The activation peptides of aspartic proteinases function as inhibitors of the protease active site. These peptide segments, or pro-parts, are deemed important for correct folding, targeting, and control of the activation of aspartic proteinase zymogens. The encoded protease may play a role in the proteolytic processing of pulmonary surfactant protein B in the lung and may function in protein catabolism in the renal proximal tubules. This gene has been described as a marker for lung adenocarcinoma and renal cell carcinoma.
Purification Method:
Affinity purification
Gene ID:
9476
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of A-549 cells, using NAPSA antibody (CAB5594) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
