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NANS Monoclonal Antibody [PAT1G6AT] (CPAB0108)

SKU:
CPAB0108
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT1G6AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

NANS Monoclonal Antibody [PAT1G6AT] (CPAB0108)

The NANs Polyclonal Antibody (CPAB0108) is a valuable tool for researchers studying NANs, a key enzyme involved in sialic acid synthesis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the NANs protein, this antibody allows for the detection and analysis of NANs levels in various cell types, making it essential for studies in glycobiology and disease research.NANs, also known as N-acetylneuraminic acid synthase, plays a crucial role in the production of sialic acid, an important component of cell surface glycoconjugates involved in cell-cell interactions and signaling pathways.

Dysregulation of NANs activity has been linked to various diseases, including cancer and neurodevelopmental disorders. Investigating the function of NANs with this specific antibody can provide insights into potential therapeutic targets for these conditions.Overall, the NANs Polyclonal Antibody is a valuable tool for researchers aiming to better understand the role of NANs in cellular function and disease pathology. Its high specificity and reliability in detecting NANs protein levels make it a crucial asset for advancing research in the field of glycobiology.

Product Name:NANS Antibody
Product Sku:CPAB0108
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NANS mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NANS amino acids 1-359 purified from Ecoli.
Clone:PAT1G6AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:NANS antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:NANS is a 359 amino acid protein that contains one AFP (antifreeze proteins)-like domain and functions in the biosynthesis of sialic acids. The ubiquitously expressed NANS enzymatically catalyzes the H2O-dependent formation of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), both of which are sialic acids. NANS uses N-acetylmannosamine 6-phosphate as a substrate for Neu5Ac synthesis and mannose 6-phosphate as a substrate for KDN synthesis.
Synonyms:Sialic acid synthase, N-acetylneuraminate synthase, N-acetylneuraminate-9-phosphate synthase, N-acetylneuraminic acid phosphate synthase, N-acetylneuraminic acid synthase, NANS, SAS.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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