The NANOS1 Polyclonal Antibody (PAC052598) is a valuable tool for researchers studying NANOS1, a protein involved in germ cell development and maintenance. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in a variety of applications, including Western blotting.NANOS1 is a conserved RNA-binding protein that plays a crucial role in regulating germ cell development and maintaining germ cell identity. Its expression is essential for proper germ cell formation in both males and females, making it a key target for studies in reproductive biology and developmental genetics.
By using the NANOS1 Polyclonal Antibody, researchers can effectively detect and analyze NANOS1 protein expression in different cell types, providing valuable insights into its function and regulation. This antibody is a valuable tool for investigating the role of NANOS1 in reproductive processes, as well as its potential implications in infertility and reproductive disorders.
Antibody Name:
NANOS1 Antibody (PACO52598)
Antibody SKU:
PACO52598
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Nanos homolog 1 protein (1-292AA)
Immunofluorescent analysis of Hela cells using PACO52598 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion.
Synonyms:
Nanos homolog 1 (NOS-1) (EC_Rep1a), NANOS1, NOS1
UniProt Protein Function:
NANOS1: May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. Belongs to the nanos family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 10q26.11Cellular Component: perinuclear region of cytoplasm; cytoplasmMolecular Function: protein binding; translation repressor activity; zinc ion binding; RNA bindingBiological Process: cell migration; negative regulation of translationDisease: Spermatogenic Failure 12
UniProt Protein Details:
NCBI Summary:
This gene encodes a CCHC-type zinc finger protein that is a member of the nanos family. This protein co-localizes with the RNA-binding protein pumilio RNA-binding family member 2 and may be involved in regulating translation as a post-transcriptional repressor. Mutations in this gene are associated with spermatogenic impairment. [provided by RefSeq, Sep 2015]
