The NALCN Antibody (PAC046798) is a highly specific and sensitive tool for researchers studying the NALCN protein, a key ion channel involved in neuronal excitability and neurotransmitter release. This polyclonal antibody, produced in rabbits, has been validated for use in various applications, including Western blot and immunofluorescence microscopy.NALCN, or sodium leak channel, non-selective, is a crucial component of neuronal function, responsible for controlling the resting membrane potential and excitability of neurons.
Dysregulation of NALCN has been implicated in various neurological disorders, such as epilepsy and developmental delay. By targeting the NALCN protein with this antibody, researchers can investigate its role in neuronal physiology and pathophysiology, enabling advancements in neuroscience research and potential therapeutic strategies for neurological diseases.
Antibody Name:
NALCN Antibody (PACO46798)
Antibody SKU:
PACO46798
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Sodium leak channel non-selective protein (19-141AA)
Immunofluorescent analysis of HepG2 cells using PACO46798 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival (By similarity).
Synonyms:
Sodium leak channel non-selective protein (CanIon) (Voltage gated channel-like protein 1), NALCN, VGCNL1
UniProt Protein Function:
VGCNL1: a putative voltage-gated ion channelProtein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral; Transporter, ion channelChromosomal Location of Human Ortholog: 13q32.3Cellular Component: plasma membrane; integral to membraneMolecular Function: voltage-gated calcium channel activity; protein binding; sodium channel activityBiological Process: sperm motility; transmembrane transportDisease: Congenital Contractures Of The Limbs And Face, Hypotonia, And Developmental Delay; Hypotonia, Infantile, With Psychomotor Retardation And Characteristic Facies
UniProt Protein Details:
NCBI Summary:
NALCN forms a voltage-independent, nonselective, noninactivating cation channel permeable to Na+, K+, and Ca(2+). It is responsible for the neuronal background sodium leak conductance (Lu et al., 2007 [PubMed 17448995]).[supplied by OMIM, Mar 2008]
