The NAK/TBK1 N-Term Rabbit Monoclonal Antibody (CAB3458) is a high-quality antibody designed for research involving the NAK/TBK1 protein, which plays a critical role in innate immune signaling pathways. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.NAK/TBK1, also known as TANK-binding kinase 1, is a serine/threonine protein kinase that is involved in the regulation of antiviral responses and inflammatory signaling pathways. Dysregulation of NAK/TBK1 has been implicated in various diseases, including autoimmune disorders, infectious diseases, and cancer.
By targeting NAK/TBK1 with this antibody, researchers can study its role in immune response modulation and potentially develop novel therapeutic strategies for related diseases.With its high specificity and sensitivity, the NAK/TBK1 N-Term Rabbit Monoclonal Antibody (CAB3458) is an essential tool for researchers conducting studies in immunology, virology, and cancer biology. Its ability to detect and analyze NAK/TBK1 protein expression in various cell types makes it a valuable asset in the quest for new insights into immune regulation and disease pathogenesis.
Product Name:
TBK1/NAK Rabbit Monoclonal Antibody
SKU:
CAB3458
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TBK1/NAK (Q9UHD2).
WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
NAK; T2K; IIAE8; FTDALS4; TBK1/NAK
Positive Sample:
293T,Hep G2,Mouse lung,Mouse testis,Rat testis
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm.
Calculated MW:
84kDa
Observed MW:
84kDa
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response.
Purification Method:
Affinity purification
Gene ID:
29110
Clone Number:
ARC0778
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TBK1/NAK Rabbit mAb (CAB3458) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
