The NAIP Polyclonal Antibody (CAB16924) is a versatile tool for researchers studying the NAIP protein, an important component of the innate immune system. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in various applications including Western blot and immunohistochemistry.NAIP, or NLR family apoptosis inhibitory protein, is involved in the regulation of apoptosis and inflammation in response to pathogens. Its role in the immune response makes it a key target for research in infectious diseases, autoimmune disorders, and inflammatory conditions.
The NAIP Polyclonal Antibody allows for the detection and analysis of NAIP protein levels in different cell types, making it an essential tool for studies in immunology and infectious disease research.Understanding the function of NAIP is crucial for developing targeted therapies and interventions for a variety of diseases. The NAIP Polyclonal Antibody aids in this research by providing accurate and reliable detection of NAIP protein levels, ultimately advancing our understanding of immune responses and potential treatment strategies.
Product Name:
NAIP Rabbit Polyclonal Antibody
SKU:
CAB16924
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 750-850 of human NAIP (NP_075043.1).
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4671
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NAIP Rabbit pAb (CAB16924) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
