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NAGK Monoclonal Antibody [P4D12AT] (CPAB0120)

SKU:
CPAB0120
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P4D12AT
Applications:
WB
ELISA
$179

Description

system_update_alt Datasheet

NAGK Monoclonal Antibody [P4D12AT] (CPAB0120)

The NAGK Polyclonal Antibody (CPAB0120) is a vital tool for researchers studying N-acetylglucosamine kinase (NAGK), an essential enzyme involved in the biosynthesis of UDP-GlcNAc, a key metabolite in cell growth and proliferation. This antibody, produced in rabbits, exhibits high specificity for NAGK in human samples and is validated for use in Western blot applications.NAGK plays a crucial role in the hexosamine biosynthetic pathway, which links glucose metabolism to post-translational modifications of proteins through glycosylation. Dysregulation of this pathway has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders.

By targeting NAGK, researchers can investigate the role of this enzyme in disease pathogenesis and potential therapeutic interventions.The NAGK Polyclonal Antibody enables the precise detection and analysis of NAGK expression in different cell types, offering valuable insights into its function and regulation. Its application in immunology and cell biology research makes it an indispensable tool for unraveling the complex mechanisms underlying diseases linked to the hexosamine biosynthetic pathway.

Product Name:NAGK Antibody
Product Sku:CPAB0120
Size:5μg
Host Species:Mouse
Immunogen:Anti-human NAGK mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human NAGK amino acids 1-344 purified from Ecoli.
Clone:P4D12AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:
Isotype:IgG1
Background:N-Acetylglucosamine Kinase (NAGK) is a part of the eukaryotic-type N-acetylglucosamine kinase family. NAGK transforms endogenous N-acetylglucosamine (GlcNAc), a main component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. NAGK is a significant salvage enzyme of amino sugar metabolism in mammals which has ManNAc kinase activity.
Synonyms:N-acetyl-D-glucosamine kinase, N-acetylglucosamine kinase, GlcNAc kinase, NAGK.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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