The NACC1 Polyclonal Antibody (CAB11720) is a valuable tool for researchers studying NACC1, a transcriptional regulator associated with cancer progression and stem cell maintenance. This antibody, produced in rabbits, demonstrates high specificity and sensitivity for detecting NACC1 in human samples, making it suitable for use in Western blot applications. By binding to the NACC1 protein, researchers can analyze its expression and function in various cell types, aiding in the investigation of its role in cancer biology and stem cell biology.
NACC1, also known as NAZ, has been implicated in promoting tumor growth and metastasis in various cancer types, making it a promising target for cancer therapy research. Additionally, NACC1 has been linked to the regulation of stem cell self-renewal and differentiation, highlighting its importance in stem cell biology. Understanding the molecular mechanisms underlying NACC1 activity is essential for developing targeted therapies and identifying potential biomarkers for cancer diagnosis and prognosis.
Product Name:
NACC1 Rabbit Polyclonal Antibody
SKU:
CAB11720
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 170-340 of human NACC1 (NP_443108.1).
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9.
Purification Method:
Affinity purification
Gene ID:
112939
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NACC1 Rabbit pAb (CAB11720) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
