The NACA2 Polyclonal Antibody (Paco42146) is a valuable tool for researchers studying NACA2, a protein involved in nucleic acid binding and protein folding. This antibody, produced in rabbits, is highly specific for human samples and is optimized for use in Western blot applications. By targeting the NACA2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it ideal for studies in molecular biology and gene regulation.NACA2, also known as nascent polypeptide-associated complex alpha subunit 2, plays a crucial role in facilitating proper folding and assembly of newly synthesized proteins. Its function in nucleic acid binding suggests involvement in transcriptional regulation and RNA processing.
Research on NACA2 is particularly relevant in understanding gene expression and protein synthesis mechanisms, with potential implications in health and disease.By characterizing the activity and interactions of NACA2, researchers can gain insights into fundamental cellular processes and potentially uncover new therapeutic targets for conditions related to protein misfolding, gene expression dysregulation, and RNA metabolism. The NACA2 Polyclonal Antibody (Paco42146) offers a reliable tool for advancing these investigations and expanding our knowledge of molecular biology.
Antibody Name:
NACA2 Antibody (PACO42146)
Antibody SKU:
PACO42146
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Nascent polypeptide-associated complex subunit alpha-2 protein (1-215AA)
Western blot. All lanes: NACA2 antibody at 5µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24 kDa. Observed band size: 24 kDa.
Background:
Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites).
NACA2: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). Belongs to the NAC-alpha family.Protein type: Unknown functionChromosomal Location of Human Ortholog: 17q23.2
