The NACA Polyclonal Antibody (CAB10122) is a valuable tool for researchers studying NACA, a protein involved in nucleosome assembly and chromatin remodeling. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in various applications, including Western blot analysis. By binding specifically to the NACA protein, this antibody allows for the accurate detection and analysis of NACA in different cell types.NACA, also known as nascent polypeptide-associated complex alpha subunit, plays a crucial role in maintaining the structure and function of chromatin, making it essential for gene regulation and DNA replication processes.
Research on NACA is particularly relevant for understanding mechanisms of gene expression and epigenetic modifications, which have implications for various biological processes and diseases.With its specificity and reliability, the NACA Polyclonal Antibody (CAB10122) is an excellent choice for studies in molecular biology, genetics, and epigenetics. Its potential applications in research areas such as cancer biology, developmental biology, and epigenetic regulation make it a versatile tool for investigating the role of NACA in health and disease.
Product Name:
NACA Rabbit Polyclonal Antibody
SKU:
CAB10122
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human NACA (NP_001106673.1).
This gene encodes a protein that associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). This complex binds to nascent proteins that lack a signal peptide motif as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. This protein is an IgE autoantigen in atopic dermatitis patients. Alternative splicing results in multiple transcript variants, but the full length nature of some of these variants, including those encoding very large proteins, has not been determined. There are multiple pseudogenes of this gene on different chromosomes.
Purification Method:
Affinity purification
Gene ID:
4666
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using NACA Rabbit pAb (CAB10122) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
