The NABP1 Polyclonal Antibody (PACO39542) is a valuable tool for researchers studying NABP1, a protein involved in DNA repair and cell cycle regulation. This antibody, produced in rabbits, specifically targets human samples and has been validated for use in Western blot applications. By binding to the NABP1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.NABP1 plays a crucial role in maintaining genomic stability and ensuring proper DNA replication, making it a key player in the prevention of DNA damage and promotion of cell survival.
Dysregulation of NABP1 has been associated with various diseases, including cancer and genetic disorders, highlighting its potential as a therapeutic target for personalized medicine approaches. By deepening our understanding of NABP1 function, researchers can uncover new insights into disease mechanisms and explore innovative treatment strategies.
Antibody Name:
NABP1 Antibody (PACO39542)
Antibody SKU:
PACO39542
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:1000-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human SOSS complex subunit B2 protein (1-204AA)
Western blot. All lanes: NABP1 antibody at 2µg/ml. Lane 1: Hela whole cell lysate. Lane 2: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 23, 14, 15 kDa. Observed band size: 23 kDa.
Background:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Synonyms:
SOSS complex subunit B2 (Nucleic acid, binding protein 1) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2A) (Sensor of single-strand DNA complex subunit B2) (Sensor of ssDNA subunit B2) (SOSS-B2) (Single-stranded DNA-binding protein 2) (hSSB2), NABP1, OBFC2A SSB2
UniProt Protein Function:
OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; DNA repair, damage; Cell cycle regulationChromosomal Location of Human Ortholog: 2q32.3Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleusMolecular Function: protein binding; RNA binding; single-stranded DNA bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation
UniProt Protein Details:
NCBI Summary:
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
