The NABP1 Polyclonal Antibody (PACO10987) is a powerful tool for researchers studying NABP1, a protein involved in DNA repair and replication processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in techniques such as Western blotting.NABP1, also known as nuclear acid binding protein 1, is essential for maintaining genomic stability by participating in the recognition and binding of DNA structures. Dysfunction in NABP1 has been linked to various diseases, including cancer and genetic disorders, highlighting its importance in cellular processes.
By utilizing the NABP1 Polyclonal Antibody, researchers can effectively detect and analyze NABP1 expression in various cell types, allowing for a deeper understanding of its function in DNA repair mechanisms. This antibody is a valuable tool for studies in molecular biology, oncology, and genetic disorders, providing insights that may contribute to the development of targeted therapies for NABP1-related conditions.
OBFC2A: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Belongs to the SOSS-B family. SOSS-B2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: DNA-binding; DNA repair, damage; Cell cycle regulationChromosomal Location of Human Ortholog: 2q32.3Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleusMolecular Function: protein binding; RNA binding; single-stranded DNA bindingBiological Process: DNA repair; double-strand break repair via homologous recombination; mitotic cell cycle checkpoint; response to DNA damage stimulus; response to ionizing radiation
UniProt Protein Details:
NCBI Summary:
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; SOSS-B2; Single-stranded DNA-binding protein 2; hSSB2
