The NAA38 Polyclonal Antibody (PAC040950) is a valuable research tool designed for studying NAA38, an essential protein involved in various cellular processes. This antibody is produced in rabbits and is highly specific to human samples, making it ideal for use in Western blot applications. By targeting the NAA38 protein, researchers can analyze its expression and function in different cell types, providing valuable insights into its role in cell biology and disease processes.NAA38, also known as NatC complex subunit NAA38, is a key player in protein acetylation and plays a crucial role in modulating protein function and stability. Its involvement in cellular pathways makes it a promising target for research related to cancer, neurodegenerative diseases, and metabolic disorders.
By studying NAA38, scientists can uncover potential therapeutic targets and develop novel strategies for treating these conditions.Overall, the NAA38 Polyclonal Antibody (PAC040950) is a valuable tool for researchers interested in unraveling the molecular mechanisms of NAA38 and its impact on cellular physiology and disease pathology. Its high specificity and reliability make it a trusted reagent for advancing scientific discoveries in the field of molecular biology and biomedical research.
Western Blot. Positive WB detected in: Mouse kidney tissue. All lanes: NAA38 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 14, 19 kDa. Observed band size: 19 kDa.
Immunofluorescence staining of PC-3 cells with PACO40950 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
IHC image of PACO40950 diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.
Synonyms:
N-alpha-acetyltransferase 38, NatC auxiliary subunit (LSM domain-containing protein 1) (Phosphonoformate immuno-associated protein 2), NAA38, LSMD1 MAK31 PFAAP2
UniProt Protein Function:
LSMD1: Component of the N-terminal acetyltransferase C (NatC) complex which may catalyze acetylation of N-terminal methionine residues. Belongs to the snRNP Sm proteins family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17p13.1Cellular Component: cytoplasm; nucleus; polysomeMolecular Function: protein bindingBiological Process: negative regulation of apoptosis
