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N6-methyladenosine / m6A Monoclonal Antibody (CAB22411)

SKU:
CAB22411
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Host Species:
Rabbit
Isotype:
IgG
Applications:
IF
€139 - €609
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:N6-methyladenosine / m6A Monoclonal Antibody
SKU:CAB22411
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Species independent
Immunogen:Chemical compounds corresponding to N6-methyladenosine / m6A.
Tested Applications:IF/ICC ELISA Nucleotide Array DB meRIP
Recommended Dilution:DB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 meRIP,1:50 - 1:200
Synonyms:N6-methyladenosine; m6A; N6-methyladenosine / m6A
Positive Sample:N6-methyladenosine / m6A, U-2 OS treated with UV(30s)Brdu(10min) cells
Observed MW:Refer to figures

Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes. m6A is widely conserved among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs with a nuclear phase. The m6A-based modification is associated with a well-defined RNA motif, RRACH (R: A/G, H: A/C/U). As a representative of the epitranscriptome, m6A mRNA modifications participate in many vital activities in the cell, including stem cell self-renewal and differentiation, mRNA transcription, alternative splicing, nuclear export, translation, degradation, and microRNA processing. These processes determine the expression or inactivation of specific genes, which is vital for growth and development.(PMID: 30416848; PMID: 24662220; PMID: 30429466)

Purification Method:Affinity purification
Gene ID:CAS:1867-73-8
Clone Number:ARC5003-03
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,0.05% BSA,50% glycerol,pH7.3.
Product ImageThe N6-methyladenosine / m6A Rabbit mAb (4µg,A19841) are tested in Nucleotide Array against N6-methyladenosine (m6A) and unmodified adenosine (100pmol for each oligomer).Oligomer 4 - N6-methyladenosine (m6A-UAACUGGACCGAAUGG-Biotin)Oligomer 5 - N6-methyladenosine (AUAACUGG-m6A-CCGAAUGG-Biotin)Oligomer 6 - unmodified adenosine (AUAACUGGACCGAAUGG-Biotin)

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