N6-methyladenosine / m6A Monoclonal Antibody (CAB22411)
- SKU:
- CAB22411
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
Product Name: | N6-methyladenosine / m6A Monoclonal Antibody |
SKU: | CAB22411 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Species independent |
Immunogen: | Chemical compounds corresponding to N6-methyladenosine / m6A. |
Tested Applications: | IF/ICC ELISA Nucleotide Array DB meRIP |
Recommended Dilution: | DB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 meRIP,1:50 - 1:200 |
Synonyms: | N6-methyladenosine; m6A; N6-methyladenosine / m6A |
Positive Sample: | N6-methyladenosine / m6A, U-2 OS treated with UV(30s)Brdu(10min) cells |
Observed MW: | Refer to figures |
Discovered in the 1970s, m6A is the most prevalent internal modification in polyadenylated mRNAs and long non-coding RNAs (lncRNAs) in higher eukaryotes. m6A is widely conserved among eukaryotic species that range from yeast, plants, flies to mammals, as well as among viral RNAs with a nuclear phase. The m6A-based modification is associated with a well-defined RNA motif, RRACH (R: A/G, H: A/C/U). As a representative of the epitranscriptome, m6A mRNA modifications participate in many vital activities in the cell, including stem cell self-renewal and differentiation, mRNA transcription, alternative splicing, nuclear export, translation, degradation, and microRNA processing. These processes determine the expression or inactivation of specific genes, which is vital for growth and development.(PMID: 30416848; PMID: 24662220; PMID: 30429466)
Purification Method: | Affinity purification |
Gene ID: | CAS:1867-73-8 |
Clone Number: | ARC5003-03 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,0.05% BSA,50% glycerol,pH7.3. |