The N Antibody (PACO52146) is a highly specific and sensitive tool for researchers studying the N protein in various applications. This polyclonal antibody has been raised in rabbits and is validated for use in Western blotting and other immunological techniques. The N protein plays a key role in viral replication and pathogenesis in Coronaviruses, making it a crucial target in the study of viral infections. This antibody binds specifically to the N protein, allowing for accurate detection and analysis in a variety of sample types.
Its high reactivity with human samples makes it an excellent choice for investigating the role of the N protein in viral diseases, including COVID-19.With its reliable performance and proven specificity, the N Antibody (PACO52146) is a valuable tool for researchers in virology, immunology, and infectious diseases. By enabling the precise identification and quantification of the N protein, this antibody contributes to our understanding of viral pathogenesis and the development of targeted treatments and vaccines.
Antibody Name:
N Antibody (PACO52146)
Antibody SKU:
PACO52146
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Lassa virus
Immunogen:
Recombinant Lassa virus Nucleoprotein protein (1-569AA)
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with β interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity).
Synonyms:
Nucleoprotein (Nucleocapsid protein) (Protein N), N
UniProt Protein Function:
Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation ().
