N Antibody (PACO50270)
- SKU:
- PACO50270
- Product Type:
- Antibody
- Reactivity:
- Virus
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
N Antibody (PACO50270)
The N Antibody (PAC050270) is a highly specific and sensitive polyclonal antibody designed for research involving the protein encoded by the N gene. This protein is a key component in viral replication and is essential for coronavirus infection. The antibody, produced in rabbits, has been validated for use in various applications, including Western blot and immunofluorescence.The N Antibody binds specifically to the N protein, allowing for accurate detection and analysis in a variety of cell types.
Its high reactivity with human samples makes it ideal for studying the mechanisms of viral replication and the immune response to coronavirus infections. Researchers in virology, immunology, and infectious diseases will find this antibody valuable for investigating the role of the N protein in viral pathogenesis and developing potential therapeutics against coronaviruses.
| Antibody Name: | N Antibody (PACO50270) |
| Antibody SKU: | PACO50270 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Junin mammarenavirus |
| Immunogen: | Recombinant Junin mammarenavirus Nucleoprotein protein (1-564AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: N antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. predicted band size: 64 kDa. observed band size: 64 kDa.. |
| Background: | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with β interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (By similarity). Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity. |
| Synonyms: | Nucleoprotein (Nucleocapsid protein) (Protein N), N |
| UniProt Protein Function: | Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Disables the host innate defense by interfering with beta interferon (IFNB) production through the inhibition of host IRF3 phosphorylation and activation by host IKBKE. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of IRF3, a protein involved in IFN activation pathway, leading to the inhibition of IFNB and IRF3-dependent promoters activation (). Interacts with host IKBKE (via Protein kinase domain); the interaction inhibits IKBKE kinase activity. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P14239 |
| NCBI GenInfo Identifier: | 127893 |
| NCBI Gene ID: | |
| NCBI Accession: | P14239.1 |
| UniProt Secondary Accession: | P14239 |
| UniProt Related Accession: | P14239 |
| Molecular Weight: | 79 kDa |
| NCBI Full Name: | Nucleoprotein |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Nucleoprotein |
| UniProt Synonym Protein Names: | Nucleocapsid protein; Protein N |
| Protein Family: | Nucleoprotein |
| UniProt Gene Name: | NÂ Â |
| UniProt Entry Name: | NCAP_JUNIN |
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