The N Antibody (PACO34230) is a polyclonal antibody specifically designed for research involving the N protein, a crucial component of viruses such as SARS-CoV-2. This antibody, derived from rabbits, is highly reactive with samples from various species and has been validated for use in applications such as ELISA and immunohistochemistry.The N Antibody binds specifically to the N protein, allowing for accurate detection and analysis in a wide range of cell types and tissues. Its versatility and reliability make it an excellent tool for studying viral infections, vaccine development, and understanding the pathogenesis of diseases caused by viruses like SARS-CoV-2.
Given the importance of the N protein in virus replication and immune response, the N Antibody is an essential resource for researchers in virology, immunology, and infectious disease. Its ability to target and detect the N protein provides valuable insights into viral biology and host immune response, facilitating advancements in the development of diagnostic tools and potential antiviral therapies.
Antibody Name:
N Antibody (PACO34230)
Antibody SKU:
PACO34230
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rabies virus
Immunogen:
Recombinant Rabies virus Nucleoprotein protein (1-450AA)
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases.
Synonyms:
Nucleoprotein (NP) (Nucleocapsid protein) (Protein N), N
UniProt Protein Function:
Encapsidates the genome in a ratio of one protein N per nine ribonucleotides, protecting it from nucleases. If expressed without protein P it binds non-specifically RNA and therefore can bind it's own mRNA. Interaction with protein P abolishes any non-specific RNA binding, and prevents phosphorylation. The soluble N-P complex encapsidates specifically the genomic RNA, with protein N protecting the genome like a pearl necklace. The encapsidated genomic RNA is termed the nucleocapsid (NC) and serves as template for viral transcription and replication. Protein N binds protein P in the NC through a different interaction, and can be phosphorylated. Subsequent viral replication is dependent on intracellular concentration of newly synthesized protein N. During replication, encapsidation by protein N is coupled to RNA synthesis and all replicative products are resistant to nucleases ().
