The Myozenin-2 Polyclonal Antibody (CAB6468) is a vital tool for researchers studying Myozenin-2, a protein associated with the regulation of striated muscle contraction and development. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to Myozenin-2, this antibody allows for the detection and analysis of the protein in various cell types, making it an essential component for research in muscle biology and cardiac function.
Myozenin-2 plays a crucial role in organizing the sarcomere structure in cardiac and skeletal muscle cells, influencing their contractile properties. Its involvement in muscle development and function makes it a key target for studying diseases such as muscular dystrophy, heart disease, and skeletal muscle disorders. Understanding the role of Myozenin-2 can provide insight into potential therapeutic strategies for these conditions, making this antibody a valuable asset for researchers in the field.
Product Name:
MYOZ2 Rabbit Polyclonal Antibody
SKU:
CAB6468
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-264 of human MYOZ2 (NP_057683.1).
The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder.
Purification Method:
Affinity purification
Gene ID:
51778
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MYOZ2 antibody (CAB6468) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
