Anti-MYOZ1 Antibody (CAB14483)
- SKU:
- CAB14483
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-MYOZ1 Antibody (CAB14483)
The MyoZ1 Polyclonal Antibody (CAB14483) is a valuable tool for researchers studying the MyoZ1 protein, a key player in muscle development and function. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the MyoZ1 protein, this antibody enables researchers to detect and analyze MyoZ1 expression in a variety of cell types, making it ideal for studies in muscle biology and related fields.MyoZ1, also known as myozenin 1, is a critical regulator of muscle structure and function, playing a role in muscle contraction and adaptation to exercise.
Understanding the function of MyoZ1 is essential for unraveling the mechanisms of muscle development, as well as for studying conditions such as muscle wasting and muscle disorders. Research on MyoZ1 may lead to new insights into muscle health and potential therapeutic strategies for muscle-related diseases.Overall, the MyoZ1 Polyclonal Antibody is a valuable tool for researchers investigating the role of MyoZ1 in muscle biology and related areas of study. Its high specificity and sensitivity make it an indispensable asset for studies aimed at elucidating the function of MyoZ1 in health and disease.
| Antibody Name: | Anti-MYOZ1 Antibody |
| Antibody SKU: | CAB14483 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-299 of human MYOZ1 (NP_067068.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | DU145, BxPC-3, A-549, Mouse liver, Mouse skeletal muscle, Mouse heart, Mouse thymus, Rat skeletal muscle |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-299 of human MYOZ1 (NP_067068.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | VFKT YISP WERA MGVD PQQK MELG IDLL AYGA KAEL PKYK SFNR TAMP YGGY EKAS KRMT FQMP KFDL GPLL SEPL VLYN QNLS NRPS FNRT PIPW LSSG EPVD YNVD IGIP LDGE TEEL |
| Gene ID: | 58529 |
| Uniprot: | Q9NP98 |
| Cellular Location: | Cell projection, Nucleus, pseudopodium |
| Calculated MW: | 31kDa |
| Observed MW: | 37kDa |
| Synonyms: | MYOZ1, CS-2, FATZ, MYOZ |
| Background: | The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. |
| UniProt Protein Function: | MYOZ1: Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Belongs to the myozenin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 10q22.1 Cellular Component: pseudopodium; nucleus; actin cytoskeleton Molecular Function:protein binding; FATZ binding Biological Process: myofibril assembly |
| NCBI Summary: | The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012] |
| UniProt Code: | Q9NP98 |
| NCBI GenInfo Identifier: | 74734300 |
| NCBI Gene ID: | 58529 |
| NCBI Accession: | Q9NP98.1 |
| UniProt Secondary Accession: | Q9NP98,Q9H1I7, |
| UniProt Related Accession: | Q9NP98 |
| Molecular Weight: | 299 |
| NCBI Full Name: | Myozenin-1 |
| NCBI Synonym Full Names: | myozenin 1 |
| NCBI Official Symbol: | MYOZ1Â Â |
| NCBI Official Synonym Symbols: | CS-2; FATZ; MYOZÂ Â |
| NCBI Protein Information: | myozenin-1; MYOZ1; calsarcin-2; filamin-, actinin- and telethonin-binding protein |
| UniProt Protein Name: | Myozenin-1 |
| UniProt Synonym Protein Names: | Calsarcin-2; Filamin-, actinin- and telethonin-binding protein; Protein FATZ |
| Protein Family: | Myozenin |
| UniProt Gene Name: | MYOZ1Â Â |
| UniProt Entry Name: | MYOZ1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MYOZ1 antibody (CAB14483) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
Related Products
Anti-TSPAN4 Antibody (CAB10253)
Anti-DNMT3A Antibody (CAB11791)
Anti-HDAC6 Antibody (CAB11261)
Anti-IkBAlpha Antibody (CAB1187)
