The Myotilin Polyclonal Antibody (CAB6439) is a powerful tool for researchers studying myotilin, a protein associated with muscle development and function. This antibody, generated in rabbits, is highly specific to human myotilin and is validated for use in Western blot applications. By binding to the myotilin protein, this antibody allows for detection and analysis in a variety of cell types, making it ideal for research in muscle biology and related fields.Myotilin is a key player in muscle organization and function, making it a crucial target for studies on muscle diseases and disorders. Dysregulation of myotilin has been linked to muscle-wasting conditions such as myofibrillar myopathies, highlighting the importance of understanding its role in muscle health.
Researchers investigating muscle degeneration, regeneration, and repair can benefit from the insights gained using the Myotilin Polyclonal Antibody.By using the Myotilin Polyclonal Antibody in their experiments, scientists can further unravel the intricate mechanisms underlying muscle development and disease, paving the way for potential therapeutic interventions for muscle-related disorders. This antibody is a valuable tool for advancing our knowledge of myotilin's function and its implications in various muscle-related conditions.
Product Name:
MYOT Rabbit Polyclonal Antibody
SKU:
CAB6439
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 259-314 of human MYOT (NP_001129412.1).
Cell membrane, Cytoplasm, Z line, cytoskeleton, myofibril, sarcolemma, sarcomere.
Calculated MW:
55kDa
Observed MW:
55kDa
This gene encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
9499
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MYOT antibody (CAB6439) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
