The Myosin-7 Polyclonal Antibody (CAB7564) is a valuable tool for researchers studying myosin-7, a motor protein involved in cellular movement and muscle contraction. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the myosin-7 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology, muscle physiology, and related fields.Myosin-7 is known for its role in various cellular processes, including cell migration, adhesion, and organelle transport. Dysregulation of myosin-7 has been linked to a range of diseases and disorders, including hearing loss, ciliopathies, and certain types of cancer.
By investigating the function and expression of myosin-7 using this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these conditions, paving the way for the development of new therapeutic strategies.Overall, the Myosin-7 Polyclonal Antibody (CAB7564) offers researchers a reliable and specific tool for studying the function of myosin-7 in both normal and diseased tissues. Its high reactivity and validated performance make it a valuable asset for advancing our understanding of the role of myosin-7 in health and disease.
Product Name:
MYH7/β-MHC Rabbit Polyclonal Antibody
SKU:
CAB7564
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1700-1800 of human MYH7/β-MHC (NP_000248.2).
Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing distal myopathy.
Purification Method:
Affinity purification
Gene ID:
4625
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using MYH7/β-MHC Rabbit pAb (CAB7564) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
