The MyoM1 Polyclonal Antibody (PAC022436) is a valuable tool for researchers studying MyoM1, a protein involved in muscle development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically targeting the MyoM1 protein, researchers can accurately detect and analyze its expression in various cell types, allowing for in-depth investigations into muscle biology and related diseases.MyoM1, also known as myomesin-1, plays a crucial role in the assembly and stabilization of the sarcomere, the basic unit of muscle structure.
Understanding the function and regulation of MyoM1 is essential for unraveling the mechanisms underlying muscle development, contraction, and disease. Researchers studying muscular dystrophies, cardiomyopathies, and other muscle-related conditions will benefit from the use of this antibody to further explore the role of MyoM1 in these pathological processes.Overall, the MyoM1 Polyclonal Antibody is a reliable tool for investigating the functions and mechanisms of MyoM1 in muscle biology, offering valuable insights into the molecular basis of muscle disorders and potential therapeutic targets.
Antibody Name:
MYOM1 Antibody (PACO22436)
Antibody SKU:
PACO22436
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human MYOM1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue using MYOM1 antibody.
Background:
Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.
Synonyms:
Myomesin-1; Myomesin family member 1; 190 kDa titin-associated protein; 190 kDa connectin-associated protein;
UniProt Protein Function:
myomesin 1: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 18p11.31Cellular Component: M band; striated muscle thick filamentMolecular Function: identical protein binding; protein binding; protein homodimerization activity; structural constituent of muscleBiological Process: positive regulation of defense response to virus by host
UniProt Protein Details:
NCBI Summary:
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
