The MYOM1 Polyclonal Antibody (PACO05617) is a valuable tool for researchers studying the MYOM1 protein, which is involved in muscle cell structure and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.MYOM1 plays a critical role in maintaining the integrity of muscle cells and is important for muscle contraction and movement. Dysregulation of MYOM1 has been implicated in muscle disorders and diseases, making it an attractive target for further research in the fields of muscle biology and neuromuscular diseases.
By using the MYOM1 Polyclonal Antibody, researchers can detect and analyze MYOM1 protein levels in various cell types, providing valuable insights into its function and potential therapeutic applications. This antibody is a valuable tool for studies aimed at understanding the molecular mechanisms underlying muscle function and dysfunction.
Antibody Name:
MYOM1 Antibody (PACO05617)
Antibody SKU:
PACO05617
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:40000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Myomesin-1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MYOM1; Myomesin-1; 190 kDa connectin-associated protein; 190 kDa titin-associated protein; Myomesin family member 1
UniProt Protein Function:
myomesin 1: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: CytoskeletalChromosomal Location of Human Ortholog: 18p11.31Cellular Component: M band; striated muscle thick filamentMolecular Function: identical protein binding; protein binding; protein homodimerization activity; structural constituent of muscleBiological Process: positive regulation of defense response to virus by host
UniProt Protein Details:
NCBI Summary:
The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD (myomesin 1) and 165 kD (myomesin 2). This protein, myomesin 1, like myomesin 2, titin, and other myofibrillar proteins contains structural modules with strong homology to either fibronectin type III (motif I) or immunoglobulin C2 (motif II) domains. Myomesin 1 and myomesin 2 each have a unique N-terminal region followed by 12 modules of motif I or motif II, in the arrangement II-II-I-I-I-I-I-II-II-II-II-II. The two proteins share 50% sequence identity in this repeat-containing region. The head structure formed by these 2 proteins on one end of the titin string extends into the center of the M band. The integrating structure of the sarcomere arises from muscle-specific members of the superfamily of immunoglobulin-like proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
