The Myocilin Polyclonal Antibody (CAB1589) is a valuable tool for researchers studying the myocilin protein, which is associated with glaucoma and other ocular diseases. This antibody, produced in rabbits, is highly specific to human myocilin and has been validated for use in a variety of applications, including Western blotting and immunohistochemistry.Myocilin plays a crucial role in the regulation of intraocular pressure and abnormalities in its function have been linked to glaucoma, a leading cause of blindness worldwide. By using the Myocilin Polyclonal Antibody, researchers can investigate the expression levels and localization of myocilin in eye tissues, providing valuable insights into the underlying mechanisms of glaucoma and potential therapeutic targets.
This antibody enables the detection and analysis of myocilin in various cell types and tissue samples, making it an essential tool for research in ophthalmology and vision science. By understanding the function of myocilin, researchers can develop new strategies for the diagnosis and treatment of glaucoma, ultimately improving the quality of life for patients affected by this sight-threatening disease.
Product Name:
MYOC Rabbit Polyclonal Antibody
SKU:
CAB1589
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 245-504 of human MYOC (NP_000252.1).
MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma.
Purification Method:
Affinity purification
Gene ID:
4653
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MYOC antibody (CAB1589) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
