The Myo3B Antibody (PAC06113) is a valuable tool for researchers interested in studying the Myo3B protein, a member of the myosin family involved in cellular transport and movement. This polyclonal antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the Myo3B protein, this antibody allows for the detection and analysis of Myo3B in various cell types, making it an ideal choice for studies in cell biology and molecular genetics.Myo3B plays a crucial role in cellular processes such as vesicle transport and actin cytoskeleton organization, making it a key target for research in fields like cell biology and neuroscience.
Understanding the function and regulation of Myo3B can provide valuable insights into cellular dynamics and disease mechanisms. By utilizing the Myo3B Antibody in their research, scientists can further elucidate the role of Myo3B in health and disease, paving the way for potential therapeutic interventions in the future.
Antibody Name:
MYO3B Antibody (PACO61113)
Antibody SKU:
PACO61113
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Myosin-IIIb protein (1110-1276AA)
IHC image of PACO61113 diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Probable actin-based motor with a protein kinase activity.
Synonyms:
Myosin-IIIb (EC 2.7.11.1), MYO3B
UniProt Protein Function:
MYO3B: an actin-based motor protein with protein kinase activity. A member of the myosin superfamily. Has a kinase domain of the STE20 family N-terminal to the conserved N-terminal motor domain. Expressed in retina, kidney and testis. Six alternatively spliced human isoforms have been described.Protein type: Kinase, protein; EC 2.7.11.1; Actin-binding; Motor; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; STE group; STE20 family; NinaC subfamilyChromosomal Location of Human Ortholog: 2q31.1-q31.2
UniProt Protein Details:
NCBI Summary:
This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
